Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.66 |
| ▸ | GSK3B | P49841 | 17/20 | 0.66 |
| ▸ | WNT1 | P04628 | 13/20 | 0.66 |
| ▸ | CLK2 | P49760 | 2/20 | 0.66 |
| ▸ | CLK3 | P49761 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23916797 | 0.81 | DYRK1A (0.65) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546947 | 0.80 | DYRK1A (0.63) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19546982 | 0.80 | DYRK1A (0.61) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916618 | 0.79 | DYRK1A (0.53) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19516547 | 0.79 | DYRK1A (1.00) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19540434 | 0.78 | GSK3B (0.73) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19540328 | 0.78 | DYRK1A (0.84) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23048710 | 0.77 | DYRK1A (0.72) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19516983 | 0.77 | GSK3B (1.00) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20949161 | 0.76 | DYRK1A (0.81) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150552-A2 | METHODS OF TREATING CARTILAGE DISORDERS THROUGH INHIBITION OF CLK AND DYRK | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |