Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498458 | 0.92 | PIM1 (0.69) | PIM1PIM3PIM2 | |
| SCHEMBL2179129 | 0.81 | PIM1 (0.77) | PIM1PIM3PIM2 | |
| SCHEMBL2179733 | 0.79 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL14768540 | 0.76 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2178777 | 0.74 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2175328 | 0.74 | PIM1 (0.79) | PIM1PIM3PIM2 | |
| SCHEMBL12498026 | 0.72 | PIM1 (0.86) | PIM1PIM3PIM2 | |
| SCHEMBL12495896 | 0.72 | PIM3 (0.88) | PIM1PIM3PIM2 | |
| SCHEMBL14762135 | 0.72 | PIM1 (0.90) | PIM1PIM3PIM2 | |
| SCHEMBL12494860 | 0.72 | PIM2 (1.00) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011080510-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2011-07-07 | — | — | WO | disclosed |