Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227933 | 0.86 | HDAC6 (0.64) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2225757 | 0.84 | HDAC6 (0.69) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2227929 | 0.82 | HDAC6 (0.61) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2227930 | 0.80 | HDAC6 (0.68) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2224925 | 0.80 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2225157 | 0.79 | HDAC6 (0.66) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2225098 | 0.78 | HDAC6 (0.62) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL1233707 | 0.78 | HDAC6 (0.72) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL19599203 | 0.78 | HDAC6 (0.69) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL6879365 | 0.78 | HDAC6 (1.00) | HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091213-A2 | REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | ACETYLON PHARMACEUTICALS (US) | 2011-07-28 | — | — | WO | claimed |