SCHEMBL22258147

SCHEMBL22258147

c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc4c(c3)sc3cccc(-c5ccc6c7ccccc7n(-c7ccccc7)c6c5)c34)n2)cc1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PDE1B Q01064 1/20 0.32
PDE3A Q14432 1/20 0.32
PDE11A Q9HCR9 1/20 0.32
LIMK1 P53667 1/20 0.32
RXFP1 Q9HBX9 2/20 0.31
HSD17B10 Q99714 1/20 0.30
PRMT5 O14744 1/20 0.30
MAT2A P31153 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23947431 0.97 KDM4E (0.35) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL22257888 0.97 KDM4E (0.34) KDM4EATML3MBTL1LIMK1
SCHEMBL26193003 0.96 KDM4E (0.36) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL22329558 0.96 KDM4E (0.38) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL23948008 0.95 KDM4E (0.34) KDM4EATML3MBTL1
SCHEMBL26193448 0.95 KDM4E (0.35) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL22257666 0.95 KDM4E (0.37) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL24221882 0.95 KDM4E (0.34) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL17252451 0.94 KDM4E (0.38) KDM4EATML3MBTL1PDE1BPDE3A
SCHEMBL23557859 0.94 KDM4E (0.35) KDM4EATML3MBTL1PDE1BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150987-A1 COMPOSITION FOR ORGANIC ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2023-05-18 US disclosed
US-20230150987-A1 COMPOSITION FOR ORGANIC ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2023-05-18 US disclosed
US-20200231578-A1 COMPOSITION FOR ORGANIC ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2020-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150987-A1 COMPOSITION FOR ORGANIC ELECTRONIC DEVICES SLCO2B1, SLCO2A1, SLCO1B3 KDM4E 3745/4885ATM 4632/4885L3MBTL1 3258/4885
US-20200231578-A1 COMPOSITION FOR ORGANIC ELECTRONIC DEVICES SLCO2B1, SLCO2A1, SLCO1B3 KDM4E 3745/4885ATM 4632/4885L3MBTL1 3258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.