SCHEMBL2226099

SCHEMBL2226099

CSc1ccc(S(N)(=O)=O)cc1CNc1cc(Nc2ccc3ncsc3c2)ncn1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 9/20 0.44
CYP3A4 P08684 1/20 0.44
JAK3 P52333 1/20 0.44
CDK1 P06493 1/20 0.43
CCNB1 P14635 1/20 0.43
CCNA2 P20248 1/20 0.43
CCNE1 P24864 1/20 0.43
CDK2 P24941 1/20 0.43
CDK5 Q00535 1/20 0.43
CDK5R1 Q15078 1/20 0.43
EGFR P00533 2/20 0.41
ERBB3 P21860 2/20 0.41
TNNI3K Q59H18 1/20 0.40
RIPK1 Q13546 1/20 0.39
PKM P14618 2/20 0.39
ALDH1A1 P00352 1/20 0.39
IKBKB O14920 3/20 0.38
RXFP1 Q9HBX9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2227241 0.83 CDK1 (0.46) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2227638 0.83 TNNI3K (0.57) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2226143 0.83 CCNA2 (0.47) JAK3CDK1CCNB1CCNA2CCNE1
SCHEMBL2226860 0.82 TNNI3K (0.45) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2228558 0.81 CDK2 (0.43) CYP3A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2225022 0.81 KDR (0.46) IRAK4CYP3A4JAK3CDK1CCNB1
SCHEMBL2225329 0.80 EGFR (0.45) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2225385 0.80 CDK1 (0.43) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2224279 0.80 EGFR (0.53) CYP3A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2226407 0.79 TNNI3K (0.42) JAK3CDK1CCNB1CCNA2CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2523559-A1 COMPOUNDS AND METHODS GlaxoSmithKline LLC (US) 2012-11-21 EP claimed
WO-2011088027-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2011-07-21 WO claimed