Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.63 |
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | JAK1 | P23458 | 5/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22261332 | 0.89 | JAK3 (0.61) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261319 | 0.88 | JAK3 (0.63) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261390 | 0.86 | JAK3 (0.63) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261177 | 0.85 | JAK3 (0.62) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL22261321 | 0.83 | JAK3 (0.60) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261224 | 0.81 | JAK3 (0.59) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261278 | 0.80 | JAK3 (0.48) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261253 | 0.79 | JAK3 (0.59) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22261183 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL22261044 | 0.78 | JAK3 (0.59) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686197-B1 | 2-SUBSTITUTED PYRAZOLE AMINO-4-SUBSTITUTED AMINO-5-PYRIMIDINE FORMAMIDE COMPOUND, COMPOSITION, AND APPLICATION THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-06-21 | — | — | EP | disclosed |
| EP-3686197-A1 | 2-SUBSTITUTED PYRAZOLE AMINO-4-SUBSTITUTED AMINO-5-PYRIMIDINE FORMAMIDE COMPOUND, COMPOSITION, AND APPLICATION THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2020-07-29 | — | — | EP | disclosed |