Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.82 |
| ▸ | JAK1 | P23458 | 16/20 | 0.71 |
| ▸ | JAK2 | O60674 | 15/20 | 0.71 |
| ▸ | TYK2 | P29597 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29949143 | 0.93 | JAK3 (0.80) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL22261025 | 0.93 | JAK3 (0.80) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL22261399 | 0.92 | JAK3 (0.81) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL22261079 | 0.92 | JAK3 (0.81) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL22261346 | 0.91 | JAK3 (0.81) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL25274920 | 0.87 | JAK3 (0.69) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL20844418 | 0.87 | JAK3 (0.70) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29622844 | 0.85 | JAK3 (0.63) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL25423678 | 0.84 | JAK3 (0.67) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL22261159 | 0.84 | JAK3 (0.79) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214230-B | 2-substituted pyrazol amino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof | 北京赛特明强医药科技有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-113214230-A | 2-substituted pyrazol amino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof | 北京赛特明强医药科技有限公司 | 2021-08-06 | — | — | CN | claimed |
| EP-3686197-B1 | 2-SUBSTITUTED PYRAZOLE AMINO-4-SUBSTITUTED AMINO-5-PYRIMIDINE FORMAMIDE COMPOUND, COMPOSITION, AND APPLICATION THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-06-21 | — | — | EP | disclosed |
| EP-3686197-A1 | 2-SUBSTITUTED PYRAZOLE AMINO-4-SUBSTITUTED AMINO-5-PYRIMIDINE FORMAMIDE COMPOUND, COMPOSITION, AND APPLICATION THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2020-07-29 | — | — | EP | disclosed |