⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718080 | 0.74 | — | — | |
| SCHEMBL2386966 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL10351867 | 0.69 | — | — | |
| SCHEMBL575165 | 0.69 | KDM4E (0.35) | — | |
| Water SCHEMBL6302124 | 0.65 | KDM4E (0.33) | — | |
| Water SCHEMBL11593563 | 0.65 | KDM4E (0.33) | — | |
| SCHEMBL1203 | 0.62 | — | — | |
| SCHEMBL14163361 | 0.61 | KDM4E (0.32) | — | |
| SCHEMBL34886 | 0.61 | — | — | |
| SCHEMBL14790911 | 0.61 | KDM4E (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154977-B1 | GLYCERIN-ETHER PHOSPHATIDES, THEIR PREPARATION AND USE | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-05-17 | — | — | EP | claimed |
| US-4694084-A | Glycerol ether phosphatides | HOFFMANN-LA ROCHE INC. (US) | 1987-09-15 | — | — | US | claimed |
| EP-0154977-A2 | Glycerin-ether phosphatides, their preparation and use | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-09-18 | — | — | EP | claimed |
| EP-2999329-A1 | LYSOPHOSPHOLIPIDS AND LYSOPHOSPHOLIPID ANALOGUES AGAINST HONEYBEE BROOD DISEASES | University of Graz (AT) | 2016-03-30 | — | — | EP | disclosed |
| EP-2526116-B1 | PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN | ST GEORGES HOSP MEDICAL SCHOOL (GB) | 2015-05-13 | — | — | EP | disclosed |
| US-8637453-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) | 2014-01-28 | — | — | US | disclosed |
| US-8541363-B2 | Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use | St George's Hosptial Medical School (GB) | 2013-09-24 | — | — | US | disclosed |
| US-20130217617-A1 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use | THE UNIVERSITY OF MANCHESTER (GB) | 2013-08-22 | — | — | US | disclosed |
| US-20120322722-A1 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use | THE UNIVERSITY OF MANCHESTER (GB) | 2012-12-20 | — | — | US | disclosed |
| WO-2011089396-A2 | PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE. | ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) | 2011-07-28 | — | — | WO | disclosed |
| EP-0154977-B1 | GLYCERIN-ETHER PHOSPHATIDES, THEIR PREPARATION AND USE | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-05-17 | — | — | EP | disclosed |
| US-4694084-A | Glycerol ether phosphatides | HOFFMANN-LA ROCHE INC. (US) | 1987-09-15 | — | — | US | disclosed |
| EP-0154977-A2 | Glycerin-ether phosphatides, their preparation and use | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-09-18 | — | — | EP | disclosed |