Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 10/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265444 | 1.00 | SPHK2 (0.49) | SPHK2SPHK1HTTCYP1A2POLB | |
| SCHEMBL22265356 | 0.97 | SPHK2 (0.53) | SPHK2SPHK1HTTCYP1A2POLB | |
| SCHEMBL22265353 | 0.97 | SPHK2 (0.53) | SPHK2SPHK1HTTCYP1A2POLB | |
| SCHEMBL29523301 | 0.89 | SPHK2 (0.45) | SPHK2SPHK1HTTCYP1A2POLB | |
| Hydrochloric Acid SCHEMBL22265986 | 0.89 | SPHK2 (0.60) | SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL22265983 | 0.89 | SPHK2 (0.60) | SPHK2SPHK1 | |
| SCHEMBL29523920 | 0.86 | SPHK2 (0.49) | SPHK2SPHK1HTTCYP1A2POLB | |
| Hydrochloric Acid SCHEMBL22265322 | 0.86 | SPHK2 (0.65) | SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL22265323 | 0.86 | SPHK2 (0.65) | SPHK2SPHK1 | |
| SCHEMBL22265767 | 0.84 | SPHK2 (0.68) | SPHK2SPHK1HTTCYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3914592-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | University of Virginia Patent Foundation (US) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |