Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 20/20 | 0.86 |
| ▸ | PRKAB2 | O43741 | 14/20 | 0.86 |
| ▸ | PRKAG1 | P54619 | 14/20 | 0.86 |
| ▸ | PRKAA1 | Q13131 | 14/20 | 0.86 |
| ▸ | PRKAG3 | Q9UGI9 | 14/20 | 0.86 |
| ▸ | PRKAG2 | Q9UGJ0 | 14/20 | 0.86 |
| ▸ | PRKAB1 | Q9Y478 | 14/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518134 | 0.93 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL10284154 | 0.84 | PRKAA2 (0.80) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL10284164 | 0.84 | PRKAA2 (0.86) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL22268938 | 0.83 | PRKAA2 (0.89) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518212 | 0.83 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL12266507 | 0.83 | PRKAA2 (0.73) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL517680 | 0.83 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL10284074 | 0.83 | PRKAA2 (0.86) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL13256096 | 0.81 | PRKAA2 (0.71) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL518471 | 0.81 | PRKAA2 (1.00) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598483-B1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |