Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | USP7 | Q93009 | 2/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227938 | 0.94 | KMT2A (0.68) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2226762 | 0.93 | SMN1; SMN2 (0.67) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2227931 | 0.90 | KMT2A (0.63) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2226942 | 0.89 | KMT2A (0.61) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2227878 | 0.87 | SMN1; SMN2 (0.70) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2218702 | 0.84 | MAPT (0.72) | KMT2ASMN1; SMN2HTTTP53NPC1 | |
| SCHEMBL2227874 | 0.83 | SMN1; SMN2 (0.65) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2226756 | 0.83 | SMN1; SMN2 (0.62) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2228741 | 0.83 | MAPT (0.70) | KMT2AMEN1SMN1; SMN2HTTTP53 | |
| SCHEMBL2219373 | 0.82 | KMT2A (0.86) | KMT2AMEN1SMN1; SMN2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | claimed |
| EP-2357176-A1 | Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7 | Hybrigenics S.A. (FR) | 2011-08-17 | — | — | EP | claimed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | claimed |
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | disclosed |
| EP-2357176-A1 | Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7 | Hybrigenics S.A. (FR) | 2011-08-17 | — | — | EP | disclosed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | disclosed |