SCHEMBL22270972

SCHEMBL22270972

CNC(=O)CC1(O)CC2CC(c3ccnc4ccc(F)cc34)CC2C1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.47
CYP2C9 P11712 5/20 0.47
TDO2 P48775 4/20 0.43
CYP2C8 P10632 3/20 0.43
CHRNA1 P02708 1/20 0.43
CYP2C19 P33261 1/20 0.43
CYP3A4 P08684 1/20 0.43
KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22270649 0.90 IDO1 (0.47) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22387361 0.89 IDO1 (0.45) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22270633 0.88 IDO1 (0.42) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22387407 0.88 IDO1 (0.45) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22270985 0.86 IDO1 (0.50) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22270713 0.86 IDO1 (0.57) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22387406 0.86 IDO1 (0.57) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22387705 0.86 IDO1 (0.57) IDO1CYP2C9TDO2CYP2C8CHRNA1
SCHEMBL22270664 0.85 IDO1 (0.48) IDO1CYP2C9TDO2CYP2C8CYP3A4
SCHEMBL22270710 0.84 IDO1 (0.45) IDO1CYP2C9TDO2CYP2C8CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3686196-A1 POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR Hangzhou Innogate Pharma Co., Ltd. (CN) 2020-07-29 EP disclosed