Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.67 |
| ▸ | CDK7 | P50613 | 12/20 | 0.67 |
| ▸ | CDK9 | P50750 | 12/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.64 |
| ▸ | CCNH | P51946 | 4/20 | 0.64 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.64 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.64 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | CASK | O14936 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | ULK1 | O75385 | 1/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.59 |
| ▸ | PAK3 | O75914 | 1/20 | 0.59 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17148352 | 0.92 | CDK2 (0.76) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL22272155 | 0.86 | CDK2 (0.64) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL22272089 | 0.86 | CDK2 (0.61) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL20583163 | 0.84 | CDK2 (0.85) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL17148348 | 0.84 | CDK2 (0.84) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL21128620 | 0.82 | CDK2 (0.71) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL18983061 | 0.81 | CDK2 (0.70) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL17148350 | 0.81 | CDK2 (0.70) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL22272118 | 0.81 | CDK2 (0.61) | CDK2CDK7CDK9CCNT1CCNH | |
| SCHEMBL22056371 | 0.80 | CDK2 (1.00) | CDK2CDK7CDK9CCNT1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129371-B1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |