Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.61 |
| ▸ | CDK9 | P50750 | 13/20 | 0.61 |
| ▸ | CDK7 | P50613 | 12/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.61 |
| ▸ | CCNH | P51946 | 6/20 | 0.61 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | CDK14 | O94921 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.54 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17148410 | 0.85 | CDK2 (0.84) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL17141859 | 0.77 | CDK2 (0.95) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL17141909 | 0.76 | CDK2 (0.78) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL17141895 | 0.76 | CDK2 (1.00) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL22272120 | 0.76 | CDK2 (0.72) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL23220919 | 0.74 | CDK2 (0.75) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL22056316 | 0.74 | CDK2 (1.00) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL22055615 | 0.74 | CDK2 (1.00) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL23664273 | 0.74 | CDK2 (0.74) | CDK2CDK9CDK7CCNT1CCNH | |
| SCHEMBL20583353 | 0.73 | CDK2 (1.00) | CDK2CDK9CDK7CCNT1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129371-B1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |