Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 20/20 | 0.69 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22272271 | 0.87 | FEN1 (0.78) | FEN1ERCC5 | |
| SCHEMBL22272254 | 0.84 | FEN1 (0.65) | FEN1 | |
| SCHEMBL29959859 | 0.82 | FEN1 (1.00) | FEN1ERCC5 | |
| SCHEMBL18670345 | 0.82 | FEN1 (1.00) | FEN1ERCC5 | |
| SCHEMBL18670511 | 0.81 | FEN1 (0.76) | FEN1 | |
| SCHEMBL29960068 | 0.81 | FEN1 (0.76) | FEN1 | |
| SCHEMBL18670589 | 0.79 | FEN1 (0.65) | FEN1 | |
| SCHEMBL29960921 | 0.79 | FEN1 (0.65) | FEN1 | |
| SCHEMBL18670584 | 0.79 | FEN1 (1.00) | FEN1 | |
| SCHEMBL29959918 | 0.79 | FEN1 (1.00) | FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11253521-B2 | 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2022-02-22 | — | — | US | disclosed |
| US-20200237763-A1 | 3-HYDROXY-QUINAZOLINE-2,4-DIONE DERIVATIVES AND THEIR USE AS NUCLEASE MODULATORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11253521-B2 | 3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators | FEN1, ERCC4, XPA | FEN1 1/4885ERCC5 22/4885 |
| US-20200237763-A1 | 3-HYDROXY-QUINAZOLINE-2,4-DIONE DERIVATIVES AND THEIR USE AS NUCLEASE MODULATORS | FEN1, ERCC4, XPA | FEN1 1/4885ERCC5 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.