SCHEMBL2227231

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2222764	0.91	MAPT (0.53)	KDM4EMAPTPOLBNPSR1L3MBTL1
	SCHEMBL2225135	0.90	S1PR1 (0.52)	KDM4EMAPTPOLBNPSR1L3MBTL1
	SCHEMBL2223906	0.88	MAPT (0.51)	KDM4EMAPTPOLBMAPK1NPSR1
	SCHEMBL2222930	0.88	KDM4E (0.49)	KDM4EMAPTPOLBMAPK1NPSR1
	SCHEMBL2224342	0.87	MAPT (0.56)	KDM4EMAPTPOLBMAPK1NPSR1
	SCHEMBL2221720	0.87	KDM4E (0.51)	KDM4EMAPTPOLBMAPK1NPSR1
	SCHEMBL2221741	0.86	KDM4E (0.57)	KDM4EMAPTPOLBNPSR1L3MBTL1
	SCHEMBL2224188	0.86	NPC1 (0.56)	KDM4EMAPTPOLBNPSR1L3MBTL1
	SCHEMBL2221001	0.86	MAPT (0.52)	KDM4EMAPTPOLBNPSR1L3MBTL1
	SCHEMBL2225364	0.86	MAPT (0.52)	KDM4EMAPTPOLBMAPK1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.