SCHEMBL2227255

SCHEMBL2227255

CSc1ccc(S(N)(=O)=O)cc1CNc1cc(Cl)ncn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 5/20 0.40
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
CCNA2 P20248 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CDK5 Q00535 1/20 0.39
CDK5R1 Q15078 1/20 0.39
TNNI3K Q59H18 1/20 0.39
SLC6A2 P23975 1/20 0.37
SLC6A3 Q01959 1/20 0.37
CA1 P00915 7/20 0.36
CA2 P00918 7/20 0.36
CA12 O43570 4/20 0.36
CA9 Q16790 4/20 0.36
ACHE P22303 1/20 0.36
LMNA P02545 1/20 0.35
CA7 P43166 2/20 0.35
CA13 Q8N1Q1 2/20 0.35
PKM P14618 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2227638 0.85 TNNI3K (0.57) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2225764 0.84 CDK1 (0.38) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2225873 0.84 TNNI3K (0.46) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2224234 0.83 TNNI3K (0.43) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2227169 0.83 CDK1 (0.40) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2226860 0.82 TNNI3K (0.45) CDK1CCNB1CCNA2CCNE1CDK2
SCHEMBL2224279 0.79 EGFR (0.53) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2227241 0.79 CDK1 (0.46) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2226407 0.79 TNNI3K (0.42) SLC6A4CDK1CCNB1CCNA2CCNE1
SCHEMBL2226143 0.79 CCNA2 (0.47) CDK1CCNB1CCNA2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2523559-A1 COMPOUNDS AND METHODS GlaxoSmithKline LLC (US) 2012-11-21 EP disclosed
WO-2011088027-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2011-07-21 WO disclosed