Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22252351 | 0.87 | CDC7 (0.44) | LMNAMAPTMEN1KMT2AATM | |
| SCHEMBL22252315 | 0.78 | TYK2 (0.44) | LMNAMAPTMEN1KMT2AATM | |
| SCHEMBL22272859 | 0.76 | CDK2 (0.49) | CDC7ROCK2PIM1PRKACACDK2 | |
| SCHEMBL22229054 | 0.76 | MEN1 (0.45) | LMNAMAPTMEN1KMT2AATM | |
| SCHEMBL22252314 | 0.73 | ELANE (0.37) | LMNAMAPTMEN1KMT2AATM | |
| SCHEMBL22252367 | 0.72 | TYK2 (0.41) | — | |
| SCHEMBL22252361 | 0.72 | TYK2 (0.47) | MEN1KMT2APOLBGSK3B | |
| SCHEMBL22272863 | 0.70 | TYK2 (0.41) | CDC7ROCK2PIM1PRKACACDK2 | |
| SCHEMBL22252343 | 0.69 | KMT2A (0.40) | LMNAMAPTMEN1KMT2AATM | |
| SCHEMBL22252603 | 0.68 | TYK2 (0.47) | ALDH1A1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154474-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-07-30 | — | — | WO | disclosed |