Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223210 | 0.94 | HRH3 (0.64) | HRH3KCNH2L3MBTL1NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL222699 | 0.88 | HRH3 (0.61) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL221776 | 0.88 | HRH3 (0.57) | HRH3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL223740 | 0.85 | HRH3 (0.65) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL222758 | 0.83 | HRH3 (0.62) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL222651 | 0.82 | HRH3 (0.67) | HRH3KCNH2ALDH1A1CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL1728317 | 0.81 | HRH3 (0.86) | HRH3KCNH2CYP3A4 | |
| SCHEMBL419180 | 0.81 | HRH3 (0.68) | HRH3KCNH2NPC1RAB9ACYP3A4 | |
| SCHEMBL2741072 | 0.81 | HRH3 (0.68) | HRH3KCNH2NPC1RAB9ACYP3A4 | |
| SCHEMBL222707 | 0.81 | HRH3 (0.68) | HRH3KCNH2NPC1RAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065234-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-15 | — | — | US | disclosed |
| US-8088808-B2 | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | SANOFI (FR) | 2012-01-03 | — | — | US | disclosed |
| EP-2212283-B1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065234-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | HRH3, HRH4, CNR1 | HRH3 1/4885KCNH2 1508/4885L3MBTL1 2586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.