Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22273577 | 0.88 | PPARA (0.45) | MAP3K8GRM4MEN1MAPTPABPC1 | |
| SCHEMBL22273578 | 0.81 | KDM4E (0.53) | MAP3K8KDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL11513455 | 0.80 | MEN1 (0.66) | FFAR1MEN1MAPTPABPC1KMT2A | |
| SCHEMBL24127052 | 0.77 | ABCG2 (0.56) | KDM4EHPGDTSHRHSD17B10GRM4 | |
| SCHEMBL19190910 | 0.77 | GRM4 (0.47) | MAP3K8FFAR1GRM4ABCG2 | |
| SCHEMBL24126805 | 0.76 | GRM4 (0.50) | MAP3K8GRM4MEN1KMT2AABCG2 | |
| SCHEMBL20714748 | 0.76 | GRM4 (0.43) | MAP3K8GRM4ABCG2HTT | |
| SCHEMBL4270413 | 0.76 | CYP3A4 (0.69) | MAP3K8KDM4ETSHRMEN1MAPT | |
| SCHEMBL16040754 | 0.76 | MEN1 (0.49) | MEN1MAPTPABPC1KMT2AHTT | |
| SCHEMBL12907086 | 0.74 | MAPT (0.52) | KDM4EHPGDMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915978-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | Hangzhou Yirui Pharmaceutical Technology Co., Ltd (CN) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020151687-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | 杭州壹瑞医药科技有限公司 | 2020-07-30 | — | — | WO | disclosed |
| CN-109651297-A | A kind of N- benzyl-N- aryl sulfonic acid amides analog derivative and preparation and application | 杭州壹瑞医药科技有限公司 | 2019-04-19 | — | — | CN | disclosed |