Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL220064 | 1.00 | HRH3 (0.63) | HRH3KCNH2CYP3A4 | |
| SCHEMBL222632 | 0.94 | HRH3 (0.70) | HRH3KCNH2CYP3A4 | |
| SCHEMBL222487 | 0.94 | HRH3 (0.70) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL2422001 | 0.87 | HRH3 (0.61) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL222819 | 0.87 | HRH3 (0.61) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL2422681 | 0.86 | HRH3 (0.77) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL2420964 | 0.85 | HRH3 (0.62) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL1728350 | 0.85 | HRH3 (0.88) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL222730 | 0.84 | HRH3 (0.66) | HRH3KCNH2CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL1729394 | 0.83 | HRH3 (0.88) | HRH3KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252824-B2 | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | SANOFI (FR) | 2012-08-28 | — | — | US | disclosed |
| US-20120065234-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-15 | — | — | US | disclosed |
| US-8088808-B2 | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | SANOFI (FR) | 2012-01-03 | — | — | US | disclosed |
| EP-2212283-B1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2011-09-21 | — | — | EP | disclosed |
| US-20100173949-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173949-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | HRH3, HRH4, CNR1 | HRH3 1/4885KCNH2 1508/4885CYP3A4 672/4885 |
| US-20120065234-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | HRH3, HRH4, CNR1 | HRH3 1/4885KCNH2 1508/4885CYP3A4 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.