Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.31 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22276178 | 0.89 | PTGER4 (0.38) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276338 | 0.87 | PTGER4 (0.39) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276343 | 0.85 | PTGER4 (0.39) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276176 | 0.85 | TBXA2R (0.37) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276339 | 0.84 | PTGER4 (0.37) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276174 | 0.83 | TBXA2R (0.34) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL23890399 | 0.83 | PTGER3 (0.36) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276144 | 0.83 | FLT1 (0.38) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276146 | 0.83 | TBXA2R (0.36) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL22276230 | 0.83 | TBXA2R (0.36) | PTGER4PTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889134-A1 | COMPOUND FOR INHIBITING PGE2/EP4 SIGNALING TRANSDUCTION INHIBITING, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF | Keythera (Suzhou) Pharmaceuticals Co. Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020151566-A1 | COMPOUND FOR INHIBITING PGE2/EP4 SIGNALING TRANSDUCTION INHIBITING, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF | 凯复制药有限公司 | 2020-07-30 | — | — | WO | disclosed |