Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | USP10 | Q14694 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227045 | 0.87 | KMT2A (0.62) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2229244 | 0.84 | KMT2A (0.65) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2229385 | 0.84 | SMN1; SMN2 (0.74) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2225718 | 0.83 | KMT2A (0.62) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2228184 | 0.81 | KMT2A (0.60) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2219299 | 0.76 | MAPT (0.58) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL14651035 | 0.75 | MAPT (0.57) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2221299 | 0.75 | USP7 (1.00) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL2218247 | 0.74 | SMN1; SMN2 (1.00) | USP7SMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL13822345 | 0.74 | MAPT (0.60) | SMN1; SMN2TP53HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | disclosed |