Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280452 | 0.90 | HTR2A (0.53) | S1PR1TLR9TLR8TLR7SPHK2 | |
| SCHEMBL22280635 | 0.85 | S1PR1 (0.54) | S1PR1TLR9TLR8TLR7NR1H4 | |
| Hydrochloric Acid SCHEMBL22265746 | 0.83 | SPHK2 (0.62) | S1PR1TLR9TLR8TLR7SPHK2 | |
| Hydrochloric Acid SCHEMBL22265618 | 0.83 | SPHK2 (0.62) | S1PR1TLR9TLR8TLR7SPHK2 | |
| SCHEMBL22280463 | 0.81 | SPHK2 (0.62) | S1PR1SPHK2 | |
| Hydrochloric Acid SCHEMBL29523175 | 0.81 | SPHK2 (0.62) | S1PR1SPHK2 | |
| SCHEMBL22280631 | 0.80 | S1PR1 (0.46) | S1PR1SPHK2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL29523923 | 0.79 | SPHK2 (0.47) | S1PR1SPHK2L3MBTL1 | |
| SCHEMBL25433735 | 0.76 | MAPT (0.54) | S1PR1NPSR1NR1H4MEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL22265421 | 0.76 | SPHK2 (0.46) | TLR9TLR8TLR7SPHK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |