Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 11/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22265512 | 0.99 | SPHK2 (0.47) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL22265514 | 0.99 | SPHK2 (0.47) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| SCHEMBL22280631 | 0.91 | S1PR1 (0.46) | SPHK2SPHK1S1PR1 | |
| Hydrochloric Acid SCHEMBL29523923 | 0.91 | SPHK2 (0.47) | SPHK2SPHK1S1PR1 | |
| Hydrochloric Acid SCHEMBL22265317 | 0.86 | SPHK2 (0.62) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL22265609 | 0.86 | SPHK2 (0.62) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL22266069 | 0.86 | SPHK2 (0.62) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL22265318 | 0.86 | SPHK2 (0.62) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL22265315 | 0.86 | SPHK2 (0.62) | SPHK2SPHK1S1PR1TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL22266067 | 0.86 | SPHK2 (0.62) | SPHK2SPHK1S1PR1TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |