Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 13/20 | 0.64 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.64 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280512 | 0.87 | SPHK2 (0.70) | SPHK2SPHK1S1PR1LMNAGAA | |
| SCHEMBL22280450 | 0.84 | SPHK2 (0.61) | SPHK2SPHK1S1PR1LMNAGAA | |
| Hydrochloric Acid SCHEMBL22265566 | 0.84 | SPHK2 (0.62) | SPHK2SPHK1S1PR1LMNAGAA | |
| Hydrochloric Acid SCHEMBL22265569 | 0.84 | SPHK2 (0.62) | SPHK2SPHK1S1PR1LMNAGAA | |
| SCHEMBL22280463 | 0.84 | SPHK2 (0.62) | SPHK2SPHK1S1PR1 | |
| Hydrochloric Acid SCHEMBL29523175 | 0.83 | SPHK2 (0.62) | SPHK2SPHK1S1PR1 | |
| Hydrochloric Acid SCHEMBL22266085 | 0.81 | SPHK2 (0.77) | SPHK2SPHK1LMNAHTT | |
| Hydrochloric Acid SCHEMBL22266082 | 0.81 | SPHK2 (0.77) | SPHK2SPHK1LMNAHTT | |
| Hydrochloric Acid SCHEMBL22265463 | 0.81 | SPHK2 (0.75) | SPHK2SPHK1S1PR1 | |
| SCHEMBL19430384 | 0.81 | SPHK2 (0.63) | SPHK2SPHK1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |