⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22404379 | 0.71 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL24648639 | 0.70 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL12654668 | 0.69 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL18841475 | 0.67 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL18841456 | 0.67 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL27050986 | 0.67 | — | — | |
| SCHEMBL23992772 | 0.67 | — | — | |
| SCHEMBL26700061 | 0.65 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL18925628 | 0.65 | CYP2D6 (0.31) | — | |
| SCHEMBL24952438 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228509-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2024-07-11 | — | — | US | disclosed |
| US-20240228509-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2024-07-11 | — | — | US | disclosed |
| US-20230399340-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2023-12-14 | — | — | US | disclosed |
| US-20230399340-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2023-12-14 | — | — | US | disclosed |
| US-20200239494-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2020-07-30 | — | — | US | disclosed |