Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22230270 | 0.87 | JAK3 (0.65) | JAK3JAK2JAK1 | |
| SCHEMBL22230267 | 0.87 | JAK3 (0.65) | JAK3JAK2JAK1 | |
| SCHEMBL22230271 | 0.87 | JAK3 (0.65) | JAK3JAK2JAK1 | |
| SCHEMBL29470598 | 0.85 | JAK3 (0.64) | JAK3JAK2JAK1 | |
| SCHEMBL22230243 | 0.84 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL22230244 | 0.84 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL22230242 | 0.84 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL29677638 | 0.84 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL22230260 | 0.84 | JAK3 (0.80) | JAK3JAK2JAK1 | |
| SCHEMBL22230258 | 0.84 | JAK3 (0.80) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154350-A1 | IMIDAZO[1,5-A]PYRIDINE, 1,2,4-TRIAZOLO[4,3-A]PYRIDINE AND IMIDAZO[1,5-A]PYRAZINE AS JAK INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2020-07-30 | — | — | WO | disclosed |