SCHEMBL22283197

SCHEMBL22283197

COc1cc2c(cc1O)N(COCC[Si](C)(C)C)C(=O)[C@@H]1C[C@@H](O[Si](C)(C)C(C)(C)C)CN1C2=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24204938 1.00
SCHEMBL17489317 0.97
SCHEMBL14090166 0.93
SCHEMBL19975842 0.90
SCHEMBL17486695 0.89
SCHEMBL24199959 0.88
SCHEMBL16067440 0.88 PDE4B (0.31)
SCHEMBL18973167 0.87
SCHEMBL22344866 0.87
SCHEMBL17476446 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606634-B2 Antibody-pyrrolobenzodiazepine derivative conjugate which binds caludin-6 and claudin-9 DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-04-21 US disclosed
US-12350344-B2 Methods of treating a tumor by administering a claudin-6 (CLDN6) or CLDN9 antibody-pyrrolobenzodiazepine derivative conjugate DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-07-08 US disclosed
US-20250114647-A1 ANTIBODY-DRUG CONJUGATES COMPRISING SUBSTITUTED BENZO[e]PYRROLO[1,2-a][1,4]DIAZEPINES DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-04-10 US disclosed
US-12246196-B2 Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-a][1,4]diazepines DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-03-11 US disclosed
US-20240299573-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-09-12 US disclosed
US-11628223-B2 Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-α][1,4]diazepines DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-04-18 US disclosed
US-20230084707-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-03-16 US disclosed
US-11583590-B2 Antibody-pyrrolobenzodiazepine derivative conjugate and method of use thereof for treating a tumor DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-02-21 US disclosed
US-20220395579-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-12-15 US disclosed
US-20220177601-A1 ANTI-HER2 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-06-09 US disclosed
US-20220168440-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DEPRIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-06-02 US disclosed
US-20220168438-A1 COMBINATION OF ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE AND PARP INHIBITOR DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-06-02 US disclosed
US-20220125943-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-04-28 US disclosed
EP-3950061-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE Daiichi Sankyo Company, Limited (JP) 2022-02-09 EP disclosed
EP-3882349-A1 (ANTI-CDH6 ANTIBODY)-(PYRROLOBENZODIAZEPINE DERIVATIVE) CONJUGATE Daiichi Sankyo Company, Limited (JP) 2021-09-22 EP disclosed
CN-113166764-A anti-CDH 6 antibody-pyrrolobenzodiazepine derivative conjugates 第一三共株式会社 2021-07-23 CN disclosed
US-20200261594-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-08-20 US disclosed
EP-3690038-A1 ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-08-05 EP disclosed