Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 15/20 | 0.46 |
| ▸ | JAK3 | P52333 | 14/20 | 0.46 |
| ▸ | JAK1 | P23458 | 13/20 | 0.46 |
| ▸ | TYK2 | P29597 | 7/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28434368 | 0.91 | FGFR1 (0.45) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL22288295 | 0.85 | JAK3 (0.46) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL29856213 | 0.85 | FGFR3 (0.41) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL29566182 | 0.85 | JAK2 (0.54) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL29960398 | 0.84 | FGFR1 (0.51) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL22288276 | 0.82 | FGFR1 (0.40) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL29856266 | 0.82 | JAK2 (0.43) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL22300590 | 0.82 | FGFR3 (0.40) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL22300160 | 0.81 | JAK3 (0.47) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL22300586 | 0.81 | JAK2 (0.54) | FGFR1FGFR2FGFR4FGFR3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484482-B | Alkynyl pyrimidine or alkynyl pyridine compound, and composition and application thereof | 北京赛特明强医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |
| WO-2020156283-A1 | ALKYNYLPYRIMIDINE OR ALKYNYLPYRIDINE COMPOUND, AND COMPOSITION AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2020-08-06 | — | — | WO | disclosed |
| CN-111484482-A | Alkynyl pyrimidine or alkynyl pyridine compound, and composition and application thereof | 北京赛特明强医药科技有限公司 | 2020-08-04 | — | — | CN | disclosed |