SCHEMBL2229036

SCHEMBL2229036

Clc1ccc2nc(-c3ccccc3)c(Cn3nnc4ccccc43)n2c1

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 12/20 0.53
TDP1 Q9NUW8 1/20 0.52
GRM2 Q14416 2/20 0.51
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
SLC9A1 P19634 2/20 0.49
GABRA2 P47869 1/20 0.47
GABRB2 P47870 1/20 0.47
KDM4E B2RXH2 1/20 0.47
HTT P42858 1/20 0.47
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2196933 0.87 TDP1 (0.51) SLC2A1TDP1GRM2MEN1KMT2A
SCHEMBL2193560 0.84 KDM4E (0.58) SLC2A1TDP1GRM2SLC9A1KDM4E
SCHEMBL1433233 0.81 SLC2A1 (0.60) SLC2A1MEN1KMT2AGABRA2GABRB2
SCHEMBL2222798 0.77 SLC2A1 (0.61) SLC2A1MEN1KMT2AGABRA2GABRB2
SCHEMBL1430426 0.76 SLC2A1 (0.59) SLC2A1MEN1KMT2AGABRA2GABRB2
Hydrochloric Acid SCHEMBL1430111 0.75 SLC2A1 (0.58) SLC2A1MEN1KMT2AGABRA2GABRB2
SCHEMBL1430034 0.74 SLC2A1 (0.55) SLC2A1MEN1KMT2AGABRA2GABRB2
Hydrochloric Acid SCHEMBL1431028 0.73 SLC2A1 (0.62) SLC2A1MEN1KMT2AGABRA2GABRB2
SCHEMBL2275313 0.72 SLC2A1 (0.58) SLC2A1MEN1KMT2AGABRA2GABRB2
SCHEMBL1430501 0.71 SLC2A1 (0.61) SLC2A1MEN1KMT2AGABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130289013-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SUNOVION PHARMACEUTICALS INC. 2013-10-31 US disclosed
US-8497278-B2 Imidazo[1,2-a]pyridine compounds SUNOVION PHARMACEUTICALS INC. (US) 2013-07-30 US disclosed
US-20110166146-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS SUNOVION PHARMACEUTICALS INC. (US) 2011-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166146-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS PAICS, ITPA, DPYD SLC2A1 2033/4885TDP1 1244/4885GRM2 1659/4885
US-20130289013-A1 IMIDAZO[1,2-a]PYRIDINE COMPOUNDS PAICS, ITPA, DPYD SLC2A1 2033/4885TDP1 1244/4885GRM2 1659/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.