Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 7/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 5/20 | 0.42 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30988055 | 1.00 | CDK8 (0.50) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL25414437 | 0.87 | CDK8 (0.44) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL22299065 | 0.87 | CDK8 (0.64) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL24399380 | 0.81 | CDK8 (0.46) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL22291200 | 0.79 | CDK8 (0.66) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL30988058 | 0.79 | CDK8 (0.66) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL25414555 | 0.76 | CDK8 (0.44) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL31536424 | 0.76 | CDK8 (0.44) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL22291196 | 0.74 | CDK8 (0.78) | CDK8CDK19RIOK2CSNK1A1CSNK1D | |
| SCHEMBL22291203 | 0.74 | CDK8 (0.64) | CDK8CDK19RIOK2CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677341-B | Bicyclic pyridine compositions and methods for their use in cancer treatment | 南卡罗莱纳大学 | 2024-07-05 | — | — | CN | disclosed |
| US-11572369-B2 | Bicyclic pyridine compositions and methods of using the same for cancer therapy | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-02-07 | — | — | US | disclosed |
| US-20220135583-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | UNIVERSITY OF SOUTH CAROLINA | 2022-05-05 | — | — | US | disclosed |
| EP-3917523-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | University of South Carolina (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160537-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | UNIVERSITY OF SOUTH CAROLINA (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160537-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | UNIVERSITY OF SOUTH CAROLINA (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135583-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | DPYD, TK2, TYMP | CDK8 289/4885CDK19 261/4885RIOK2 1878/4885 |
| US-11572369-B2 | Bicyclic pyridine compositions and methods of using the same for cancer therapy | DPYD, TK2, TYMP | CDK8 289/4885CDK19 261/4885RIOK2 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.