Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17647565 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ENPSR1GAAALDH1A1 | |
| SCHEMBL29818557 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ENPSR1GAAALDH1A1 | |
| SCHEMBL14698246 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4ENPSR1GAAALDH1A1 | |
| SCHEMBL17648733 | 0.74 | KDM4E (0.55) | SMN1; SMN2KDM4ENPSR1GAAALDH1A1 | |
| SCHEMBL14698115 | 0.74 | SMN1; SMN2 (0.36) | SMN1; SMN2KDM4ENPSR1GAAALDH1A1 | |
| SCHEMBL29818371 | 0.74 | SMN1; SMN2 (0.36) | SMN1; SMN2KDM4ENPSR1GAAALDH1A1 | |
| SCHEMBL15116256 | 0.72 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4ENPSR1GAAPPARG | |
| SCHEMBL1105461 | 0.71 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4ENPSR1GAAPPARG | |
| SCHEMBL23782997 | 0.68 | KDM4E (0.43) | SMN1; SMN2KDM4ENPSR1GAAPPARG | |
| SCHEMBL7913221 | 0.67 | KDM4E (0.50) | SMN1; SMN2KDM4EGAAPPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3203840-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2020-08-05 | — | — | EP | disclosed |