Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | LCAT | P04180 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23866054 | 0.88 | CCR6 (0.34) | CCR6HRH3ESR1ACACBNR1H2 | |
| SCHEMBL22296208 | 0.83 | CHRM4 (0.39) | EGFRBTK | |
| SCHEMBL17660305 | 0.81 | MAPT (0.46) | CCR6HRH3 | |
| SCHEMBL24746187 | 0.81 | PIK3CA (0.37) | HRH3EGFRBTK | |
| SCHEMBL24747235 | 0.81 | PIK3CA (0.37) | HRH3EGFRBTK | |
| SCHEMBL23865949 | 0.81 | EGFR (0.36) | HRH3EGFRBTKLCAT | |
| SCHEMBL17055343 | 0.81 | PIK3CA (0.37) | HRH3EGFRBTK | |
| SCHEMBL23108883 | 0.80 | CCR6 (0.43) | CCR6 | |
| SCHEMBL23103745 | 0.80 | CCR6 (0.43) | CCR6 | |
| SCHEMBL23114413 | 0.80 | CCR6 (0.43) | CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |