Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TET3 | O43151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | FBXL19 | Q6PCT2 | 3/20 | 0.40 |
| ▸ | CXXC5 | Q7LFL8 | 3/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.40 |
| ▸ | CXXC4 | Q9H2H0 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.40 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19909654 | 0.93 | USP2 (0.41) | USP2CYP3A4CYP2D6CYP2C19BTK | |
| SCHEMBL22296240 | 0.92 | CYP3A4 (0.55) | USP2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL24542942 | 0.91 | CYP3A4 (0.39) | USP2CYP3A4CYP2D6CYP2C19BTK | |
| SCHEMBL16078760 | 0.91 | USP2 (0.42) | USP2CYP3A4CYP2D6BTKHSD17B10 | |
| SCHEMBL20849781 | 0.83 | TET3 (0.45) | USP2BTKTET3KMT2AFBXL19 | |
| SCHEMBL3934383 | 0.81 | USP2 (0.47) | USP2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16127680 | 0.81 | JAK3 (0.42) | USP2BTKTET3KMT2AFBXL19 | |
| SCHEMBL16380252 | 0.81 | USP2 (0.44) | USP2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL18711889 | 0.79 | USP2 (0.49) | USP2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL24543075 | 0.79 | TET3 (0.40) | BTKTET3KMT2AFBXL19CXXC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |