Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17361131 | 0.79 | FGFR4 (0.34) | FGFR4TEAD1 | |
| SCHEMBL17361133 | 0.79 | FGFR4 (0.34) | FGFR4TEAD1 | |
| SCHEMBL21706978 | 0.79 | EGFR (0.37) | EGFRERBB3BTKTEAD1 | |
| SCHEMBL24928079 | 0.78 | OGA (0.36) | MAPK1SSTR4SSTR1 | |
| SCHEMBL10513011 | 0.78 | OGA (0.36) | MAPK1SSTR4SSTR1 | |
| SCHEMBL10513014 | 0.78 | OGA (0.36) | MAPK1SSTR4SSTR1 | |
| SCHEMBL29445632 | 0.77 | — | — | |
| SCHEMBL20326345 | 0.76 | JAK3 (0.40) | EGFRBTKMAPK1TEAD1 | |
| SCHEMBL20326578 | 0.71 | TSHR (0.32) | EGFRERBB3MAPK1TEAD1 | |
| SCHEMBL23690731 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |