Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | BMX | P51813 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296211 | 0.90 | BTK (0.67) | BTKJAK3EGFR | |
| SCHEMBL22296210 | 0.88 | BTK (0.67) | BTKJAK3EGFRLCK | |
| SCHEMBL22296415 | 0.88 | BTK (0.67) | BTKJAK3EGFRLCK | |
| SCHEMBL22296238 | 0.85 | BTK (0.72) | BTKJAK3EGFRBMXITK | |
| SCHEMBL23865978 | 0.85 | BTK (0.68) | BTKJAK3EGFRBMXLCK | |
| SCHEMBL23865959 | 0.83 | BTK (0.66) | BTKJAK3EGFRBMX | |
| SCHEMBL22296205 | 0.82 | BTK (0.58) | BTKJAK3EGFR | |
| SCHEMBL22222659 | 0.81 | BTK (0.83) | BTKJAK3EGFR | |
| SCHEMBL16207084 | 0.81 | FLT3 (0.70) | BTKJAK3EGFRRETROS1 | |
| SCHEMBL22296421 | 0.80 | BTK (0.72) | BTKJAK3EGFRBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |