Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31453504 | 0.87 | RCE1 (0.44) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL5139238 | 0.87 | RCE1 (0.44) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL7228724 | 0.80 | TSHR (0.44) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL7157545 | 0.79 | RCE1 (0.43) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL20034084 | 0.78 | RCE1 (0.35) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL3127875 | 0.75 | HCAR2 (0.51) | RCE1TSHRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL3127891 | 0.75 | HCAR2 (0.51) | RCE1TSHRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6172748 | 0.74 | SLC1A3 (0.47) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL9250351 | 0.74 | RCE1 (0.45) | RCE1TSHRMAPTSLC1A3SLC1A2 | |
| SCHEMBL6239311 | 0.74 | SLC1A3 (0.47) | RCE1TSHRMAPTSLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |