Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 3/20 | 0.40 |
| ▸ | CDK8 | P49336 | 3/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10049906 | 0.83 | GAA (0.48) | GAANPSR1THRBAKR1C3AKR1C2 | |
| SCHEMBL14676881 | 0.81 | NPSR1 (0.40) | NPSR1CCNCCDK8SMN1; SMN2L3MBTL1 | |
| SCHEMBL10242686 | 0.79 | GAA (0.54) | GAATHRBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL604399 | 0.79 | GAA (0.54) | GAATHRBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6876035 | 0.79 | SMN1; SMN2 (0.46) | NPSR1CCNCCDK8SMN1; SMN2NPC1 | |
| SCHEMBL24884200 | 0.78 | NPSR1 (0.38) | NPSR1CCNCCDK8SMN1; SMN2KDM4E | |
| SCHEMBL12985068 | 0.78 | GAA (0.53) | GAATHRBAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2822660 | 0.77 | GAA (0.49) | GAATHRBATMSMN1; SMN2HSD17B10 | |
| SCHEMBL865863 | 0.77 | KDM4C (0.40) | NPSR1CCNCCDK8SMN1; SMN2NPC1 | |
| SCHEMBL20743181 | 0.76 | NPSR1 (0.37) | NPSR1CCNCCDK8SMN1; SMN2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023217879-A1 | PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |