SCHEMBL22308115

SCHEMBL22308115

C[C@@H](NC(=O)C(=O)c1cc(C(=O)O)c2n1CCC2)C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC10A1 Q14973 2/20 0.48
KCNK3 O14649 18/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28631357 1.00 SLC10A1 (0.48) SLC10A1KCNK3
SCHEMBL22308116 1.00 SLC10A1 (0.48) SLC10A1KCNK3
SCHEMBL28638202 0.98 SLC10A1 (0.46) SLC10A1KCNK3
SCHEMBL28638198 0.98 SLC10A1 (0.46) SLC10A1KCNK3
SCHEMBL28630773 0.86 SLC10A1 (0.44) SLC10A1KCNK3
SCHEMBL28630776 0.86 SLC10A1 (0.44) SLC10A1KCNK3
SCHEMBL22307699 0.85 PDE3B (0.50) SLC10A1KCNK3
SCHEMBL28636397 0.85 PDE3B (0.50) SLC10A1KCNK3
SCHEMBL22307724 0.85 PDE3B (0.50) SLC10A1KCNK3
SCHEMBL21809982 0.79 KCNK3 (0.38) SLC10A1KCNK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113365999-B Capsid protein assembly inhibitors containing pyrroloheterocycles 正大天晴药业集团股份有限公司 2023-04-14 CN disclosed
CN-113365999-A Capsid protein assembly inhibitors containing pyrroloheterocycles 正大天晴药业集团股份有限公司 2021-09-07 CN disclosed
WO-2020156494-A1 CAPSID PROTEIN ASSEMBLY INHIBITOR CONTAINING PYRROLO HETEROCYCLE 正大天晴药业集团股份有限公司 2020-08-06 WO disclosed