SCHEMBL22308306

SCHEMBL22308306

CN1CCc2oc(C(C)(C)C)nc2C1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 2/20 0.34
CYP2C19 P33261 1/20 0.33
CYP3A4 P08684 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32
LMNA P02545 1/20 0.31
BLM P54132 1/20 0.31
PMP22 Q01453 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8277483 0.77 CHRM3 (0.37) CHRM3CYP2C19CYP3A4TSHRHSD17B10
SCHEMBL1106414 0.72 CHRM3 (0.34) CHRM3CYP2C19CYP3A4TSHRHSD17B10
SCHEMBL22308307 0.72 HPGD (0.35)
SCHEMBL16869975 0.71 DPP4 (0.39) CHRM3CYP2C19CYP3A4TSHRHSD17B10
SCHEMBL17090680 0.68 CYP2C19 (0.53) CHRM3CYP2C19LMNA
SCHEMBL30785553 0.68 DPP4 (0.37) CHRM3CYP2C19LMNA
SCHEMBL12691717 0.68 GRM5 (0.55) CYP2C19
SCHEMBL20329006 0.67 CHRM3 (0.33) CHRM3
SCHEMBL322302 0.66 KMT2A (0.46)
SCHEMBL3585302 0.66 S1PR5 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020156323-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2020-08-06 WO disclosed