Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 6/20 | 0.52 |
| ▸ | GUSB | P08236 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | WNT1 | P04628 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308390 | 0.90 | KDM4E (0.57) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL22308394 | 0.89 | KDM4E (0.61) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL22307975 | 0.89 | KDM4E (0.58) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL22307956 | 0.86 | KDM4E (0.64) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL954666 | 0.84 | KDM4E (0.64) | KDM4EMAPK10HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL22307981 | 0.84 | KDM4E (0.63) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL22308392 | 0.84 | KDM4E (0.76) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL22307946 | 0.84 | KDM4E (0.69) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL4517828 | 0.83 | KDM4E (0.81) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 | |
| SCHEMBL22307953 | 0.83 | KDM4E (0.61) | KDM4EMAPK10HSD17B10ITKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | KDM4E 1414/4885MAPK10 254/4885HSD17B10 3991/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | KDM4E 2440/4885MAPK10 234/4885HSD17B10 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.