Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22311326 | 1.00 | NR1H2 (0.51) | NR1H2NR1H3PDK2GPR119NPC1 | |
| SCHEMBL30451037 | 1.00 | NR1H2 (0.51) | NR1H2NR1H3PDK2GPR119NPC1 | |
| SCHEMBL22310596 | 0.96 | NR1H2 (0.52) | NR1H2NR1H3PDK2GPR119THRB | |
| SCHEMBL30451676 | 0.96 | NR1H2 (0.52) | NR1H2NR1H3PDK2GPR119THRB | |
| SCHEMBL22311353 | 0.96 | NR1H2 (0.52) | NR1H2NR1H3PDK2GPR119THRB | |
| SCHEMBL30452461 | 0.93 | NR1H2 (0.55) | NR1H2NR1H3PDK2GPR119NPC1 | |
| SCHEMBL22284291 | 0.93 | NR1H2 (0.55) | NR1H2NR1H3PDK2GPR119NPC1 | |
| SCHEMBL22284292 | 0.93 | NR1H2 (0.55) | NR1H2NR1H3PDK2GPR119NPC1 | |
| SCHEMBL20060924 | 0.93 | NR1H2 (0.55) | NR1H2NR1H3PDK2GPR119NPC1 | |
| SCHEMBL22311330 | 0.89 | NR1H2 (0.63) | NR1H2NR1H3PDK2GPR119NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200247754-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247754-A1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | NR1H2, NR1H3, NR1H4 | NR1H2 1/4885NR1H3 2/4885PDK2 2381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.