Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29472235 | 1.00 | POLQ (0.40) | POLQHSD17B10KDM4EGAAMAPT | |
| SCHEMBL29472243 | 0.87 | POLQ (0.52) | POLQHSD17B10KDM4EGAAMAPT | |
| SCHEMBL22312015 | 0.87 | POLQ (0.52) | POLQHSD17B10KDM4EGAAMAPT | |
| SCHEMBL7498311 | 0.79 | GPBAR1 (0.43) | KDM4EMAPTTP53GPBAR1MLNR | |
| SCHEMBL22289623 | 0.77 | POLQ (0.53) | POLQGAAMAPTTP53LMNA | |
| SCHEMBL29472250 | 0.77 | POLQ (0.53) | POLQGAAMAPTTP53LMNA | |
| SCHEMBL22312009 | 0.76 | POLQ (0.52) | POLQKDM4EGAAMAPTTP53 | |
| SCHEMBL7509248 | 0.75 | TSHR (0.46) | POLQHSD17B10KDM4EMAPTTP53 | |
| SCHEMBL22312028 | 0.75 | POLQ (0.64) | POLQHSD17B10KDM4EGAAMAPT | |
| SCHEMBL22312046 | 0.74 | POLQ (0.50) | POLQKDM4EGAAMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160134-A1 | ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |