Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.48 |
| ▸ | BCR | P11274 | 5/20 | 0.48 |
| ▸ | ACACB | O00763 | 4/20 | 0.42 |
| ▸ | ACACA | Q13085 | 4/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431362 | 1.00 | ABL1 (0.48) | ABL1BCRACACBACACADDR1 | |
| SCHEMBL22314579 | 0.75 | DDR1 (0.43) | ABL1BCRACACBACACADDR1 | |
| SCHEMBL22314495 | 0.75 | HPGD (0.51) | ABL1BCRACACBACACAGRM4 | |
| SCHEMBL29431495 | 0.75 | DDR1 (0.43) | ABL1BCRACACBACACADDR1 | |
| SCHEMBL29431508 | 0.75 | HPGD (0.51) | ABL1BCRACACBACACAGRM4 | |
| SCHEMBL22314362 | 0.75 | ADORA2A (0.43) | ACACBGRM4HPGDCCNCCDK8 | |
| SCHEMBL29431327 | 0.75 | ADORA2A (0.43) | ACACBGRM4HPGDCCNCCDK8 | |
| SCHEMBL29431419 | 0.74 | ACACB (0.42) | ABL1BCRACACBACACA | |
| SCHEMBL22314580 | 0.74 | ACACB (0.42) | ABL1BCRACACBACACA | |
| SCHEMBL24463671 | 0.74 | ABL1 (0.41) | ABL1BCRACACBACACAGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160151-A1 | 15-PGDH INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2020-08-06 | — | — | WO | disclosed |