Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2616855 | 0.87 | ATM (0.48) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL3585115 | 0.85 | NOTUM (0.56) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL30575716 | 0.85 | NOTUM (0.56) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL29985319 | 0.84 | MAPT (0.49) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL395684 | 0.84 | MAPT (0.49) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL11962995 | 0.84 | MAPT (0.52) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL2616894 | 0.84 | MAPT (0.47) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL399528 | 0.82 | NOTUM (0.51) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL4426865 | 0.80 | MAPT (0.55) | ATMMAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL4425962 | 0.80 | MAPT (0.57) | ATMMAPTSMN1; SMN2PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738016-B2 | BRD4-kinase inhibitors as cancer therapeutics | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738016-B2 | BRD4-kinase inhibitors as cancer therapeutics | BRD4, BICRA, BRDT | ATM 673/4885MAPT 3403/4885SMN1; SMN2 4754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.