Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.78 |
| ▸ | TP53 | P04637 | 10/20 | 0.78 |
| ▸ | MDM4 | O15151 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223282 | 1.00 | MDM2 (0.78) | MDM2TP53MDM4 | |
| SCHEMBL220998 | 1.00 | MDM2 (0.78) | MDM2TP53MDM4 | |
| SCHEMBL220997 | 1.00 | MDM2 (0.78) | MDM2TP53MDM4 | |
| SCHEMBL223066 | 0.94 | MDM2 (0.85) | MDM2TP53MDM4 | |
| SCHEMBL223067 | 0.94 | MDM2 (0.85) | MDM2TP53MDM4 | |
| SCHEMBL221656 | 0.93 | MDM2 (0.80) | MDM2TP53MDM4 | |
| SCHEMBL221657 | 0.93 | MDM2 (0.80) | MDM2TP53MDM4 | |
| SCHEMBL220671 | 0.92 | MDM2 (0.88) | MDM2TP53MDM4 | |
| SCHEMBL1958495 | 0.92 | MDM2 (0.88) | MDM2TP53MDM4 | |
| SCHEMBL16787958 | 0.92 | MDM2 (0.66) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088815-B2 | Spiroindolinone pyrrolidines | HOFFMAN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088815-B2 | Spiroindolinone pyrrolidines | HOFFMAN-LA ROCHE INC. (US) | 2012-01-03 | — | — | US | disclosed |