⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12870029 | 0.89 | — | — | |
| SCHEMBL9124893 | 0.80 | — | — | |
| SCHEMBL907299 | 0.80 | — | — | |
| Hydrogen Peroxide SCHEMBL9691732 | 0.80 | — | — | |
| SCHEMBL20603981 | 0.80 | — | — | |
| Ammonia Solution, Strong SCHEMBL4604413 | 0.80 | — | — | |
| SCHEMBL15952163 | 0.80 | — | — | |
| SCHEMBL420432 | 0.80 | — | — | |
| SCHEMBL1052945 | 0.80 | — | — | |
| Phosphine SCHEMBL22499763 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757349-B2 | Use of cilastatin to reduce the nephrotoxicity of different compounds | FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2017-09-12 | — | — | US | disclosed |
| US-20170035718-A1 | USE OF CILASTATIN TO REDUCE THE NEPHROTOXICITY OF DIFFERENT COMPOUNDS | FUND PARA LA INVESTIG BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2017-02-09 | — | — | US | disclosed |
| US-9522128-B2 | Use of cilastatin to reduce the nephrotoxicity of different compounds | FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2016-12-20 | — | — | US | disclosed |
| US-20160136121-A1 | USE OF CILASTATIN TO REDUCE THE NEPHROTOXICITY OF DIFFERENT COMPOUNDS | FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2016-05-19 | — | — | US | disclosed |
| US-9216185-B2 | Use of cilastatin to reduce nephrotatoxicity of various compounds | FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2015-12-22 | — | — | US | disclosed |
| EP-2143429-B1 | Use of cilastatin to reduce the nephrotoxicity of different compounds | FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2013-11-20 | — | — | EP | disclosed |
| US-20110165264-A1 | USE OF CILASTATIN TO REDUCE NEPHROTATOXICITY OF VARIOUS COMPOUNDS | FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON (ES) | 2011-07-07 | — | — | US | disclosed |
| EP-2143429-A1 | Use of cilastatin to reduce the nephrotoxicity of different compounds | Fundacion para la Investigacion Biomedica Del Hospital Gregorio Marañon (ES) | 2010-01-13 | — | — | EP | disclosed |
| EP-0085328-B1 | IMPROVED PROCESS FOR FORMING NITROPARAFFIN | W.R. GRACE & CO. (US) | 1986-11-12 | — | — | EP | disclosed |
| EP-0173775-A1 | Improved process for forming nitroparaffins | W.R. GRACE & CO. (US) | 1986-03-12 | — | — | EP | disclosed |
| US-4476336-A | Process for forming nitroparaffin | W. R. GRACE & CO. (US) | 1984-10-09 | — | — | US | disclosed |
| US-4458094-A | Process for forming nitroparaffin | W. R. GRACE & CO. (US) | 1984-07-03 | — | — | US | disclosed |
| EP-0085328-A1 | Improved process for forming nitroparaffin | W.R. GRACE & CO. (US) | 1983-08-10 | — | — | EP | disclosed |