Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 6/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350007 | 0.80 | JAK3 (0.44) | JAK3JAK2JAK1LCK | |
| SCHEMBL2233927 | 0.73 | JAK2 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL2229902 | 0.71 | PCSK9 (0.41) | JAK3 | |
| SCHEMBL22364301 | 0.71 | JAK2 (0.66) | JAK3JAK2JAK1 | |
| SCHEMBL2346942 | 0.67 | JAK2 (0.48) | JAK3JAK2JAK1 | |
| SCHEMBL2347670 | 0.67 | JAK3 (0.45) | JAK3JAK2JAK1HCRTR1LCK | |
| SCHEMBL20240132 | 0.65 | JAK2 (0.48) | JAK3JAK2JAK1 | |
| SCHEMBL2231299 | 0.64 | JAK3 (0.44) | JAK3JAK2JAK1BTKLCK | |
| SCHEMBL2230590 | 0.64 | DYRK1A (0.35) | — | |
| SCHEMBL15192871 | 0.64 | EIF2AK4 (0.41) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101161-A1 | PYRAZOLE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |
| EP-2360158-A1 | Pyrazole derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-08-24 | — | — | EP | disclosed |