Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14261646 | 1.00 | BTK (0.62) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL14261648 | 1.00 | BTK (0.62) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL14270420 | 1.00 | BTK (0.62) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL13337688 | 1.00 | BTK (0.62) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL14270414 | 1.00 | BTK (0.62) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL2988884 | 1.00 | BTK (0.62) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL573239 | 0.91 | BTK (0.55) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL573238 | 0.91 | BTK (0.55) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL5473239 | 0.91 | BTK (0.55) | BTKKDM1AMAOBCTSKCA1 | |
| SCHEMBL29366241 | 0.90 | BTK (0.77) | BTKKDM1AMAOBCTSKCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3527573-B1 | SYNTHESIS OF POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS | GILEAD SCIENCES INC (US) | 2020-08-12 | — | — | EP | disclosed |